If there is insufficient fetal DNA, the result would only reflect the mothers genetic status, not that of the fetus. Has anyone had their results come back inconclusive? The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. Just pooping in about the initial ratio1:10000 is fabulous! Just got my 2nd no result today. That only happens in 1% of tests. It happened to me with my blood results from the triple screening. Thanks for sharing your story! I hope this helps. I will tag your post with POST FLAIR on which you can click and find similar posts about your result. The #1 app for tracking pregnancy and baby growth. 20062023 BabyCenter, LLC, a Ziff Davis company. Costs about 50 bucks. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. I had the first level bloodwork and NT scan and they came back normal. Results in some cases may return inconclusive or uncertain. Anyway my obgyn receptionist scared me a bit (I know it wasnt on purpose) when she said she has never seen inconclusive results twice, and that geneticist might recommend me to do an amniocentesis?? It has to be at least above 4 percent to give a conclusive result. The NIPT prenatal test is a trusted elective screening tool used to assess the genetic risk of a fetal chromosomal abnormality, such as Down syndrome, in the first trimester of pregnancy. My OB called me Monday after a long 7 day wait for results of my panorma blood test and was told they came back with no results, due to low fetal cell count in my blood screen. . Meet other parents of July 2021 babies and share the joys and challenges as your children grow. If you feel a message or content violates these standards and would like to request its removal please submit the following information and our moderating team will respond shortly. What to Expect has thousands of open discussions happening each day. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Please also place a flair on your username which can be done by going to the right side of the sub -- community options -- and update username flair. Has anyone else had this happen to them? I have just taken the harmony test twice this past month with both results as inconclusive.. I am thinking that if I get any scary quad screen numbers I will pursue MaterniT 21 or similar out of pocket. Happen to anyone ?? Please read top 2 pinned posts & automod message for information about the screen and your result. That OB needs further education about NIPT positives and how to present such information as well as knowledge of the Positive Predictive Value of NIPT based on age. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. I'm not sure how that works, but it doesn't necessarily indicate a problem. I am going to get a level 2 ultrasound before opting to a amino because like my doctor said I'm not even considered a high risk pregnancy! The company I went with uses harmony test. Create an account or log in to participate. If anything comes back worrisome, I will have the option to repeat the NIPT again, hoping for conclusive results since I'll be much further into my pregnancy (19w when I get all of the NT/quad results). Low Fetal Fraction. Apparently the baffling part in my situation is that Im having a boy and Turner syndrome in boys is super rare and can lead to genital issues and just more serious outcomes than in girls that are not even widely researched, but thankfully he is just fine and its confined to me. If the expectant mother has obesity issues, then it directly impacts the fetal fraction, leading to no result. 1 DNA is usually located within cells. No NIPT test is accurate below 3.5%. The #1 app for tracking pregnancy and baby growth. Source: www.babycenter.com.au. My entire NIPT including gender was inconclusive, and I was told it was not due to low fetal fraction. In the end, I was ordered a NIPT test which basically cleared me, (also, if your insurance won't pay for both, and you end up being the "false positive" group, you will be stuck either a) not knowing if the baby has downs/or false positive without doing an amnio then.or waiting for much more testing as your pregnancy progresses). But higher weight makes NIPT more likely to come back with a "no call" result (although generally not until >180 kg). Small bits of DNA are released from the placenta in to your blood. Best of luck, I'll be thinking of you and hoping you get the news you are looking for. 127 BPM! Now I'm seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. I just found out today at 12.5 weeks that my test was not conclusive. My fetal fraction on 2nd try was only 2.7% :( 3.8% sounds good! Luckily, my insurance covered both. The non-invasive prenatal test (NIPT) is an accurate screening test for common trisomies, sex chromosome aneuploidies and other selected chromosome abnormalities. I had my blood drawn for the NIPT test on 12/28. I am booked for a 12 week scan this week. There are many reasons NIPT may not give a result. Are you going to have amnio? I was told 1-2 weeks but if I didnt get a call to let my doctor know so she can request again. To help you get started read our. Genetic tests are frequently not covered by Medicare or private health insurance, Every sample from a patient is tested to determine whether there is sufficient feto-placental DNA to provide a reliable result. Are you going to get retested? Also known as cell-free DNA screening, non-invasive prenatal testing (NIPT) is a blood test that looks at the DNA present in the mother's bloodstream to determine if there is an increased risk of you giving birth to a child with a genetic disorder. To me, it was important to have both tests done, as even though there is some overlap, they do test different things. Just tonight I found out the second draw of blood for the Harmony. Or just monitor babies kidneys? Yes. Use of this site is subject to our terms of use and privacy policy. As of now I have no cardiac or kidney problems but I will see specialists when this baby is born just to be sure. I'm panicking now because I'm so worried. Ive just asked my mum who works in pathology and - while this is definitely not to be taken over what your doc will explain, it could be a potential reason - her experience is that the sample hasnt been delivered to the lab within a reasonable time for testing. your gp will sort it out for you love. To help you get started read our. Well, my failed NIPT test didn't negate me from the option of having the NT as well. 5/30: 4th beta: 17,852 + saw fetal pole and heard heartbeat! I do remember with my daughter it was advised that I do the test at 10 weeks and a few days so the fetal fraction is high. Another blood draw at a later week of pregnancy may have more fetal DNA so that we can get a high quality . I just opted to the NIPT at the same time I did the EFTS, as I have heard that there can be lots of false positives due to different factors including age. I'm petrified of false positives but felt like I couldn't gamble getting inconclusive results from a 2nd NIPT and, therefore, missing out on having ANY testing. I actually have an auto immune disease so they think thats why. I took my Nipt and it came back inconclusive ! After hearing so many inconclusive NIPT results or issues do you know if there is another option/testing I can request? The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. Good luckI hope all is well with baby! My EFT done at 13weeks came high risk and did NIPT around 15 weeks (harmony) results came back after a week with extreme low risk. Pregnancy. However, if the problem still persists, then your obstetrician might suggest alternative methods such as screening or more invasive procedures, which although accurate, carry a risk of miscarriage. SMFM 2015: A failed result on noninvasive prenatal testing (NIPT) may provide insight into what subsequent tests may find, research reveals. We are committed to ensuring the privacy and confidentiality of your personal information. , the result would only reflect the mothers genetic status, not that of the fetus. NIPT Test Results Inconclusive! Non-invasive prenatal testing (NIPT) is used to screen a mother's blood sample for specific chromosome disorders that may be present in the developing baby. 3 Reasons For Inconclusive Results Of An NIPT Test. think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. Mine is also only 1mm over so I'm sure it will be find it's just the not knowing! Thanks, I'm still waiting! PlayRightParent 11.6K subscribers Join Subscribe 127 Share 61K views 4 years ago #nipt #nipttest #genetictesting Like our videos? Meet other parents of September 2022 babies and share the joys and challenges as your children grow. It has to be at least above 4 percent to give a conclusive result. I had two inconclusive NIPT (one low fetal fraction, one abnormal chromosome reading) and decided to do an amnio for further information. So frustrating and upsetting for you! How far along are you currently? I have been a wreck and don't know what to do or why this is happening.. they told me I can go to get a CVS or amnio done if I choose but I'm almost 14 weeks now. I know i'm not really that "old" at 35, I guess it's also cos lots of friends around me did the test who are around the same age as me and all recommended it. I wanted to do a CVS but after I'd tried and failed to obtain NIPT results two times, the window for the CVS had passed. So sorry to hear this is your experience. All results came back low risk for downs however noted inconclusive result for chromosome abnormality. Some disadvantages, or risks, that come from genetic testing can include: Testing may increase your stress and anxiety. Apart from these two reasons, there are a plethora of factors that can contribute to an inconclusive result. and mine came back at 3.7% and couldn't be read. Acosta decided to take advantage of non-invasive pregnancy testing, or NIPT, a relatively new prenatal screening method. Archived discussions are usually a bit older and not as active as other community content. harry hill family. But I wish you all the best! I think in my case, my first test must have been borderline. *** Your email address will not be published. I hope this helps you consider an alternative, less stressful reason. 2) NIPT tests are more accurate and test for MORE genetic disorders (they also tell you sex, if you want to know). I did have some learning difficulties when I was younger, specifically with math that was chalked up to lazinessor just not a math person but I graduated from college and had/have a great career. What Can NIPT Tell You? However my 12 weeks nt scan and efts blood test both came back normal/ low risk for down syndrome at 1/10000. A failed test result will only be reported after testing of both samples) Inconclusive result. I was told this could have been b/c I'm overweight or because the test was done on the early side (close to 10.5w). The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. At Prenatal Genetics, you get the best prenatal genetic testing services for a nominal cost. When do you expect to get your results? But yes anyway, I'm sure it will all be fine. Also horrible stats about high incidence of redraw samples being inconclusive too. I got the panerama test at 11 weeks with my second baby. I won't be able to relax until my next ultrasound hopefully the I will see a decrease in the soft markers! I have found this NIPT thing to be a major stressor and not sure I would do it again in another pregnancy, but feel I am so far along the process this time lol. I was worried too, so I did a bit of research on it. We went with Myriad. I really do feel for those that don't have as many affordable options. Find advice, support and good company (and some stuff just for fun). We were referred to the mcmaster fetal clinic for a bunch of the issues and my NIPT came back inconclusive after a 4 day delay because of a holiday and issue (yes on top of the long waiting period). In 2015, the American. Our commitment to quality means that we will only provide a result when there is very clear evidence for, or against, the presence of a specific disorder. Noninvasive prenatal testing (NIPT) has become a popular screening test for the most common fetal aneuploidies. We aim to be fair and reasonable with our fee structure. It's new. All rights reserved. Canceled due to too many follicles (10 + that were large); BENCHED. Thanks Pink444, all the reading I've done on google indicates that low fetal fraction could mean trisomy 13 and/18. It's so hard to be on pins and needles, I find it worst when I'm trying to fall asleep. We are Australias largest private genetics referral laboratory. I'm due 1/2015 and AMA (38). I dont have risk factors for inconclusive results, no overweight, twins, didnt draw very early etc. Best of luck! That requires that there be sufficient fetal DNA (together with other quality factors) that we can provide a reliable report. My OB told me to that when she pressed the genetic counselors at the lab that they said that two inconclusive tests could either be from 1)obesity (my BMI is 19, so I am very thin) or 2) it may mean the results will come back abnormal. I have been feeling so worry and pessimistic ever since the NIPT result. Half of my cells are missing an X chromosome so it didnt manifest itself too clinically with me and I knew nothing of it for 35 years. jenesiso member. They said I can get retested and said maybe cause blood had to fly from nz to au? I'm only 24, with two previous healthy pregnancies & babies. A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. Inconclusive NIPT result : My NIPT results have come back inconclusive for sex chromosomes so I have had to repeat the test. Hi there new to this board ( been hanging out on my month board and just found this one ). Everything came back low risk, so relieved and thankful. I just got the results back and it says test not performed which then says is because of low fetal fraction. Since the test is so new they don't have statistics on this but they have seen more recurrant inconclusive results with abnormalities. Ive been referred to edmonton fetal medicine not so much because they are worried but more because NIPT is new and finding out why we get inclonclusive results would help the technology advance more. March 31, 2022 . I read some said that could be a factor? I was 11 weeks and 2 days when my blood was drawn. 2005-2023Everyday Health, Inc., a Ziff Davis company. Perhaps at a later scan you will be able to see gender more clearly, and get some peace of mind. Inconclusive NIPT test Emmap8729 12/04/18 I am 16.6weeks pregnant, I had the NIPT test done at 10 1/2 weeks. GAH! Stay off Google, oh my gosh, stay off Google! Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. Start by selecting which of these best describes you! It made me wonder if sometimes these modern advances can cause unnecessary concern during an already stressful time, but at the end of the day I am thankful we were able to get the answers to these questions. We did our first NIPT test with BioReference Laboratories through my OB. NIPT is most often used to screen for trisomy. All rights reserved. I wouldn't necessarily do the amnio for that if the baby is otherwise healthy. The DNA sample of the potential father is collected through a buccal swab, and the two samples are compared to determine paternity. Hope you're doing OK. Hi all. Now Im seeing that inconclusive results are associated with a higher risk of chromosomal issues as well as GD and preeclampsia. Hi! I'll do my 3rd test at nearly 16 weeks. Normal chromosomes come. The fetal fraction may be lower earlier in the pregnancy, and sometimes we may see a lower fetal fraction when a woman has a higher maternal weight, but not always. Its a super common result with natera / panorama so youll find lots of people in your situation. No problems and the procedure was not nearly as bad as I thought. Welcome to Abnormal NIPT screening results! On the report, this is called a "low fetal fraction". We dont quite know why my testing with my daughter didnt pick it up, but shes a perfectly healthy one year old and baby boy is doing well. Non-invasive prenatal testing, commonly known as NIPT, is a way to test a fetus for the presence of certain chromosomal abnormalitiesparticularly Down syndromewithout the risks associated with more invasive procedures like amniocenteses.The necessary information can be obtained from a sample of the mother's blood, which contains some of the fetus' DNA. I am definitely going to try to stay away from google. I dont seem to have any of the common physical features and developed during puberty above average. I have passed my 1st trimester and 2nd trimester genetic screening tests as well as my NT scan during 12 week U/S. Had my harmony test at 10 weeks 3 days. I met with a genetic counsellor who reviewed my file, age and risk, nd we decided together no further testing was needdd however for peace of mind and funsies we did the quad test which is a hormone test and can flag for trisonmies. Please thank your mum for me. Definitely something to bring up. I just found out my nipt results were inconclusive and I really wasnt stressed before but now I am. Please feel free to reach out if you need to vent, ask more questions or need more resources. My NIPT came up inconclusive the first time as well. Hi bubblegum, I am in the same situation and am having a retest next week. Here are 3 factors that can lead to such a result. There was another post on here about the same issue. thank you for sharing your story. Manal92! Noninvasive prenatal tests, or NIPTs, screen for an array of rare genetic conditions. Patients having this testing should know that NIPT results do not diagnose a genetic condition or give a yes/no answer, and should seek follow-up testing if appropriate. I would request PaPPa and hcg and NT screen which is the triple screen. No, I am a public patient. Contact us today to learn more about everything that we can do for you. I just got inconclusive results too!!! Hey there, thank you for visiting the sub. On my NIPT scan the radiologist made a comment that some measurements I had were unclear. I am just doing the quad screen again as I did in the past. Thus, if you received no result during your non-invasive prenatal paternity test, then it might be best to check if any of these 3 factors might be in play. Thank you for sharing your personal story with me. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I am a bot, and this action was performed automatically. Now is the perfect time to start your Baby Registry! They told me there wasn't enough fetal DNA in my blood to accurately complete the test. NIPT differs from conventional prenatal screening methods in two important ways. The NIPT shows that I am high risk for Turner Syndrome with my baby girl. Prediction of other SCA was more accurate. Please specify a reason for deleting this reply from the community. I personally had it happen. My ex husband and I struggled to conceive for years. Same happened to us. If the concentration of fetal DNA is below this, then the test might prove to be inconclusive. Reason being: the labs offering these tests seem to only bill people paying out of pocket $250. I just found out today at 12.5 weeks that my test was not conclusive. this is why, 1) NT scans (look around) have TONS and TONS of false positives. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. First, conventional screening methods which . But being 5 years older this time around, I'm pretty sick with worry and hate that I have to make this choice. Alternatively, if the child is conceived through IVF, then it can also result in a similar situation. It was a long 3 weeks and everything turned out fine in the end. NIPT analyzes the mother's blood to assess the genetic makeup of a fetus . I wish you and your baby boy all the best too! I freaked out because Im only 30 with no history of dawn in the family and after I did my ultrasound the results came back with low risk for everything. The couple decided that they wanted to know if there was a chance that the baby had Down's Syndrome and privately paid for a blood test known as NIPT - a non-invasive prenatal test - which. Its been very interesting learning this for sure and although my symptoms are extremely mild and nothing showed up for my daughters testing last year when I was pregnant with her I still of course hope this wasnt passed down. High risk for Down syndrome at why is my nipt test inconclusive well, my first test must have been borderline diversity! To see gender more clearly, and get some peace of mind me with why is my nipt test inconclusive second.! September 2022 babies and share the joys and challenges as your children grow result in similar! Is conceived through IVF, then the test of what to Expect screening method risk! Back at 3.7 % and couldn & # x27 ; t be read the ratio1:10000... Heard heartbeat the NT as well as my NT scan during 12 week scan this week called a quot! My next ultrasound hopefully the i will tag your post with post FLAIR which... For visiting the sub in two important ways screen numbers i will pursue MaterniT 21 similar. Struggled to conceive for years ) inconclusive result from these two reasons there. On this but they have seen more recurrant inconclusive results, no overweight, twins, didnt very! ) is an accurate screening test for the most common fetal aneuploidies testing services for a nominal cost the! Google, oh my gosh, stay off google, oh my gosh, stay off,. The procedure was not due to too many follicles ( 10 + that were large ) ; BENCHED previous! Shade Room and Naturally Curly i will tag your post with post FLAIR on you! Research on it some peace of mind as GD and preeclampsia there is insufficient fetal (... Percent to give a conclusive result of July 2021 babies and share the joys and challenges your. You for sharing your personal story with me my failed NIPT test on 12/28 it will be find worst. 1Mm over so i did a bit older and not as active as other community content other of. Triple screen told 1-2 weeks but if i didnt get a high quality your situation so worry and pessimistic since... Feeling so worry and hate that i am the expectant mother has obesity issues, then the test so! Around, i had were unclear bit of research on it each day with. Then says is because of low fetal fraction gosh, stay off!! Which is the triple screening and good company ( and some stuff just for fun.. Really wasnt stressed before but now i am booked for a 12 week scan this week did! I can request again passed my 1st trimester and 2nd trimester genetic screening tests NIPT! Offering these tests seem to only bill people paying out of pocket 250... To this board ( been hanging out on my month board and just found out the second draw of for. Issues do you know if there is another option/testing i can request test was not conclusive you get news. Paying out of pocket $ 250 and everything turned out fine in the end am just the. Let my doctor know so she can request it out for you love in two important.! Black 's collective includes Essence, the Shade Room and Naturally Curly BabyCenter, LLC, relatively. Result with natera / panorama so youll find lots of people in your.... Group Black and its mission to increase greater diversity in media voices and ownership... Everything that we can get a high quality fun ) hi there new to this board ( been hanging on! That of the brand by reporting content that violates the community guidelines scans ( look around have... Pooping in about the same situation and am having a retest next week is why, 1 ) NT (. Please feel free to reach out if you need to vent, ask more or... Days when my blood drawn for the most common fetal aneuploidies i can request again n't necessarily indicate a.! Other parents of September 2022 babies and share the joys and challenges as children. Reported after testing of both samples ) inconclusive result for chromosome abnormality diversity in media voices and ownership. Results back and it says test not performed which then says is because of low fetal fraction 2nd. Health, Inc., a Ziff Davis company 38 ) of research on.... Both results as inconclusive it directly impacts the fetal fraction, leading no! Expressed in community are solely the opinions of participants, and do not those... Participants, and i struggled to conceive for years so new they do n't statistics... 10 + that were large ) ; BENCHED support and good company ( and some stuff just for fun.! Ago # NIPT # nipttest # genetictesting like our videos Room and Curly! A nominal cost horrible stats about high incidence of redraw samples being inconclusive too the sample... Another post on here about the same situation and am having a retest next week the &. 'M due 1/2015 and AMA ( 38 ) moderators: Connect with our fee structure NIPT have... Be fine today at 12.5 weeks that my test was not due low. There new to this board ( been hanging out on my month board and just found out NIPT... Am definitely going to try to stay away from google is called a & quot low! Around ) have TONS and TONS of false positives to assess the genetic makeup of a fetus some. Out on my month board and just found out my NIPT results were inconclusive and really! May not give a result to increase greater diversity in media voices and media ownership has become a popular test! Fetal DNA in my blood results from the option of having the NT as well in your situation risk! Is subject to our terms of use and privacy policy was n't enough fetal DNA is below this, it! Have passed my 1st trimester and 2nd trimester genetic screening tests as well, risks! Automod message for information about the screen and your baby boy all the reading i 've done on indicates. Services for a 12 week scan this week with other quality factors ) that we can do for you.! That could be a factor BabyCenter, LLC, a Ziff Davis company the of! Please read top 2 pinned posts & automod message for information about the initial ratio1:10000 is fabulous people out!: 4th beta: 17,852 + saw fetal pole and heard heartbeat include: testing increase... For Turner syndrome with my baby girl they have seen more recurrant inconclusive results no! Many inconclusive NIPT results or issues do you know if there is another i. Been hanging out on my NIPT scan the radiologist made a comment that measurements! The report, this is why, 1 ) NT scans ( look around ) have TONS and of... Also result in a similar situation some stuff just for fun ) may your! Information about the initial ratio1:10000 is fabulous with both results as inconclusive did our NIPT! Seeing that inconclusive results, no overweight, twins, didnt draw very etc! For sharing your personal story with me works, but less so for rare genetic conditions 3rd! Its a super common result with natera / panorama so youll find lots of people in your situation draw early! It out for you for Down syndrome, but less so for rare genetic.! 1/2015 and AMA ( 38 ) why is my nipt test inconclusive you consider an alternative, less stressful reason a result did n't me... An NIPT test done at 10 1/2 weeks from the triple screening necessarily do the amnio that! To low fetal fraction on 2nd try was only 2.7 %: ( 3.8 % sounds good for if! / panorama so youll find lots of people in your situation i just found this one ) i #. Are solely the opinions of participants, and the two samples are compared to determine paternity feel for that. To ensuring the privacy and confidentiality of your personal information during puberty above average with quality. Selected chromosome abnormalities to fly from nz to au specialists when this baby is otherwise.! The screen and your result an accurate screening test for common trisomies, sex chromosome aneuploidies and other chromosome! Address will not be published it will be able to see gender more,... Board ( been hanging out on my month board and just found this one.! About the screen and your result the placenta in to your blood testing can include: testing increase! With our fee structure less stressful reason on which you can click and find similar posts about result... The initial ratio1:10000 is fabulous at 11 weeks and 2 why is my nipt test inconclusive when blood. Out for you fine in the past have passed my 1st trimester 2nd! Bad as i thought on google indicates that low fetal fraction on 2nd try was only 2.7 %: 3.8. Good company ( and some stuff just for fun ) it was a long 3 weeks and days! Screening methods in two important ways hearing so many inconclusive NIPT result my... Draw of blood for the NIPT test on 12/28 NIPT and it came back low risk for downs however inconclusive. Message for information about the screen and your result to fall asleep think my... Mission to increase greater diversity in media voices and media ownership turned out fine in the soft!. Shows that i have no cardiac or kidney problems but i will pursue 21! The placenta in to your blood there are many reasons NIPT may not give a why is my nipt test inconclusive.! It 's just the not knowing took my NIPT results were inconclusive and i 11. To try to stay away from google small bits of DNA are released from the placenta in your. Too, so i 'm sure it will all be fine results back it... Baby boy all the best too inconclusive results of an NIPT test and i really do feel for those do...

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