We just got our results back and have a perfectly healthy eggo. This is called the fetal fraction. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Certain prenatal screening tests like NIPT are very accurate for conditions such as Down syndrome, but less so for rare genetic conditions. Here's an overview of a study with more information about the link between low fetal DNA and trisomy risks. It's probably your BMI. No, its not necessary. I have been so scared the last 2 weeks thinking about this because theres really been a lack of info about what this could mean from my doctors office. However, if the presence of a trisomy would affect your decision, then I'd personally opt for the amnio--however it's a 100% personal choice and there are arguments to be made for both sides. Note that once you confirm, this action cannot be undone. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. k[oku6Av9j12U}BOn.jQ5-W],W7N~x ;)R7M 9z:FC& Q~Ro1!. No markers or bright spots. This just proves that getting inconclusive results doesnt always mean something is wrong. NIPT testing is optional. Obviously not out of the woods but the good news is all I needed to keep tracking forward with positivity. I dont have any advice. Has anyone experienced this? - September 2021 Birth Club - BabyCenter Canada Home Community September 2021 Birth Club Inconclusive NIPT twice! Create an account to follow your favorite communities and start taking part in conversations. You definitely are not obese! My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didn't tell me over the phone what it was. , I agree with PP. I'll be around 18 weeks by then. Reading these posts makes me wonder if this happens more often than I thought. It has a heartbeat of 142 but doctor said that hes still very guarded about the pregnancy and strongly advised for the CVS which I will do. I didn't have this with my first child so I'm not sure if they can tell the sex via ultrasound at 16 weeks. I am so sorry this has happened twice! Learn more about, Twins & Multiples: Your Tentative Time Table. : Inconclusive NIPT twice. . The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. A place for pregnant redditors, those who have been pregnant, those who wish to be in the future, and anyone who supports them. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). The stresfull part is that they suggest that low fetal fraction can be liked to trosimies.. These tests diagnose conditions and give a yes or no answer: Its important to discuss the results of your NIPT with your provider so you have all the information you need to determine the next steps. Yes with Natera Panaroma, I had inconclusives twice & declined the third redraw. This educational content is not medical or diagnostic advice. Theres also the possibility that no test results are given due to insufficient fetal DNA in your blood or difficulty identifying fetal DNA. Your test result shows that your pregnancy is at low risk for these three conditions. Create an account to follow your favorite communities and start taking part in conversations. My first pregnancy resulted in a miscarriage at 8 weeks. Wish we did like other pregnancies and skipped the testing! Amnio specialist also told me that low fetal fraction can be because of placenta. endstream endobj 70 0 obj <>/Metadata 17 0 R/PageLayout/OneColumn/Pages 67 0 R/StructTreeRoot 23 0 R/Type/Catalog/ViewerPreferences<>>> endobj 71 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text/ImageC]/XObject<>>>/Rotate 0/StructParents 0/Tabs/S/Type/Page>> endobj 72 0 obj <>stream We do not have labs here that does NIPT, but we can submit blood sample and they send it to USA. Try not to wig out I know its easier said than done but just stay focused on the positives youre pregnant again! And like pp said.I hope your anatomy scan is smooth sailing and you can see that the baby is fine and healthy. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Noninvasive prenatal testing (NIPT), sometimes called noninvasive prenatal screening (NIPS), is a method of determining the risk that the fetus will be born with certain genetic abnormalities. I'm pretty sure its because I'm overweight lolmanyjow dehydration sounds like a good idea although the first day I went I had puked all morning Anyhow am skipping it now and will just wait till my next appointment which is on the 20th and hopefully we will find out the gender. By rejecting non-essential cookies, Reddit may still use certain cookies to ensure the proper functionality of our platform. I ended up asking for a quad screen (it wasnt covered by my insurance but was like $30) to assess risk for trisomy 21, 18 and spina bifida. Would you get the NIPT test if you were me? Please specify a reason for deleting this reply from the community. Have a child with a chromosomal abnormality. Healthcare providers may recommend it if you: The American College of Obstetricians and Gynecologists (ACOG) used only to recommend NIPT for pregnant people considered high risk. Had to redraw today and start the waiting process all over. I would have preferred to skip the test altogether if I had known. She made it seem like I would definitely get the chance for a second blood draw at a later date and it would almost certainly work. I have read that maternal obesity can be a factor, my BMI is 27 so overweight but not obese. It's a screening test offered during pregnancy to see if the fetus is at risk for having a chromosomal disorder like Down syndrome (trisomy 21), trisomy 18 (Edwards syndrome) and trisomy 13 (Patau syndrome). This test can be done beginning at 10 weeks of pregnancy. So I just found out that my NIPT came back with low fetal fraction for the second time. 15/01/2022 20:53. They didn't even bother to retest mine when the first try came back inconclusive because they assumed it wouldn't work since I'm obese. Fed up with comments on here "trust me, you will have a 8 week abdominal ultrasound - cant see much? Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. As far as 16 weeks ultrasound, sex was pretty obvious on mine . The #1 app for tracking pregnancy and baby growth. also people mentioned placenta issues above! I also have this which is why Im on aspirin - here in the lu they check your blood at 12 weeks to find out about your placenta ! 19 weeks tomorrow. 2005-2023Everyday Health, Inc., a Ziff Davis company. Reddit and its partners use cookies and similar technologies to provide you with a better experience. I didn't do a NIPT (just the NT scan) so no personal experience! hb``c``Zp7XX8LN`` Husband upset I dont want his family to visit for at Why do so many women like to give birth without medication? My doctor didnt seem too concerned, as apparently they come back inconclusive all the time. rU%`_@j)4KYm9"PR Xb@{i#n->`#4sI2n# ! Well this clinic doesnt ask people to come back. What was the outcome? This just happened to me today, I didn't really want the DNA test but my husband wanted peace of mind. The most common sex chromosome conditions are Turner syndrome, Klinefelter syndrome, Triple X syndrome and XYY syndrome. NIPT Inconclusive Twice - Any Success Stories After No Result l Ladylawyer8402 Posted 6/19/20 So I just found out that my NIPT came back with low fetal fraction for the second time. However, they got all the ones they needed for the NIPT which were good. How do health care providers diagnose birth defects? Also, all of the anatomy scans have come back perfect. I received a phone call from my midwife today and she informed me that my second Panorama test can back inconclusive due to low fetal fraction. Hi all, just an update. The #1 app for tracking pregnancy and baby growth. If you dont have insurance or your insurance doesnt cover NIPT tests, you can pay for the test. Mine came back inconcl, I was 12 weeks and then took again at 14 1D, I have also had 2 inconclusive results and we are not trying again. My BMI is a bit high and I've read that can be a reason. Your healthcare provider will receive your test results first, then share the results with you. Inconclusive just means they couldn't get a reading. I dont understand why it didnt work for me. Its a personal choice, and its normal to have questions. Has this happened to anyone else? I did my NIPT bloods today & they mentioned that for around 2% of people there just isnt enough fetal DNA to measure, no matter how many times they retest. I have a high risk of 1/175. Has anyone had this happen to them or know someone? Press question mark to learn the rest of the keyboard shortcuts. Can I ask how your Quad screening went? However my 12 weeks NT scan and EFTS blood test both came back normal/ low risk for . Get useful, helpful and relevant health + wellness information. I have read this is an issue for plus size women and . This is my second baby and I didnt do NIPT with my first. NIPT testing doesnt diagnose conditions it only suggests a fetus is more likely to have a particular condition. Im so so sorry to hear about your loss. I am very plus size and this did happen to me during my last pregnancy but they got results on the second redraw. Same thing happened to me. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know why this could happen. thank you - apparently triploidy is not linked to maternal age - Im 29 and it could have happened to an 18 year old or a 40 year old mother. Its important to remember that a screening test estimates the likelihood of the fetus having a particular condition. Group Leaders communicate with staff moderators and escalate potential violations for review, but they dont moderate discussions. Use of this site is subject to our terms of use and privacy policy. Basically they know I am coming back for the anatomy scan and the radiologist attempted to do a mini anatomy off the scans the technician got but that either the baby wasnt in the proper spot or it was too soon to make those comments until I am 20 weeks. your experiences with being fat an needing IVF/ICSI? The test can also determine the sex of the fetus. My doc told me 2 inconclusive tests raises the risk level significantly in my age. NIPT stands for noninvasive prenatal testing. The test can also determine the sex of the fetus. The minimum they require to release the results is 2.8%, and the first draw I had 3.2% for 1 baby and 2.2% for the other. Press J to jump to the feed. The results will be on this week for a few things but up to 2 weeks for everything. insufficient DNA for the NIPT test) and chances of a trisomy defect. I realize I may have been taking about something different. hbbd``b` $X-  H *H2M) u$B@> LW@b!3.|` I would be very frustrated. Im sick to my stomach and waiting on them to call me back to discuss a recommendation on next steps. The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. What tests might I need during pregnancy? 2005-2023Everyday Health, Inc., a Ziff Davis company. I had the test done again about 2 weeks later and just got results today. Has this happened to anyone? You will likely be able to find out the sex at an ultrasound at 16 or 20 weeks just fine. Can I ask how your Quad screening went? I can tell you that if you don't want to wait, the sneak peek test still works just fine if you can afford it. It can't do genetic risks though. Same situation here! Or chromosomes? NIPT is a screening test and, therefore, isnt perfect. Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. My next appt is my anatomy scan and it isnt until Nov 30! @Woofwoofbarkbark ya I definitely want to know as early as possible, t13/t18 have such such high chance of late miscarriage etc I need to be prepared if this was a chance To comment on this thread you need to create a Mumsnet account. Thats why the screening isnt performed until 10 weeks into the pregnancy. At this point I am 20w, yes it can be - t13 & t18 but it can be linked to a lot of things! I am so confused and stressed. My first test was at 10 weeks (FF=4.8%) and my second was at 14 weeks-she didnt tell me over the phone what it was. Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. Hey lovely - where are you based? Were you referring to the harmony test? Lab is saying I could try a third time but no guarantees it will work. DNA makes up a persons genes and chromosomes, and gives healthcare providers a glimpse into the fetuss genetic makeup. Good luck!! Inconclusive NIPT results twice : hello, just wondering if this has happened to anyone? I didn't know size may have factored into it, thanks for sharing! A Group Owner is a member that has initiated the creation of a group to connect with other members to share their journey through the same pregnancy & baby stages. april731 5 yr. ago That's very reassuring. So I'm not sure how it was for you. Strangely enough, I am also on lovenox.I am also old at 39 and have a higher BMI. I'm sorry you weren't told! yeah I declined the redraw also and decided to wait. New comments cannot be posted and votes cannot be cast. Does knowing this information make me sad, anxious or feel prepared to care for the baby? Other factors like being pregnant with multiples, being a surrogate or having obesity can affect NIPT results. It's not like my weight was a surprise to them. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. If you'd continue the pregnancy regardless of any defects, then I think you can definitely skip the amnio. It just depends on the baby. Both said due to low fetal DNA at 2.6% and 2.7% respectively. For example, you may get a positive or high-risk result for trisomy 13 but a negative or low-risk result for Down syndrome. I had to do the NIPT test twice. It might be more trouble than it's worth to do a third draw, esp with a different company, but I thought I'd mention it so that you know it's potentially an option. It's normal. The reason why we cannot report a specific test usually reflects the complex biology of genetics and pregnancy, and is not due to a technical failure in the laboratory. Out of curiosity I contacted this particular clinic for clarification and they told me that they write this on many patents NIPT. The views expressed in community are solely the opinions of participants, and do not reflect those of What to Expect. They could have also just waited until 16 weeks for my first blood draw given my weight. I agree with PP. Theyre not sure what caused the inconclusives, but theyre screening and not diagnostics, so it could just be in error. Are you doing the NT scan & bloods as well? I wouldnt have survived with out those ladies. I have an early anatomy scan on Wednesday with an MFM due to my history of GD and age. Understanding what the NIPT test results mean. Yes, mine came back inconclusive as well. Im waiting for those NIPT results and still have two weeks to go before my anatomy scan. (https://pubmed.ncbi.nlm.nih.gov/26781507/), Visitation, mask requirements and COVID-19 information. My Hi all,I had my first NIPT labs drawn around 10 weeks. The first time it came back inconclusive due to low fetal fraction. I had the first done at 13w and second done at 16w. The NIPT test is also called cell-free DNA (cfDNA) screening or noninvasive prenatal screening (NIPS). Your healthcare provider will discuss all your prenatal screening options, including NIPT. Your healthcare provider will provide information about prenatal genetic testing and help you make an informed choice about your options. How far along were you when you took each one? The reason that your doctor is suggesting an ammio is because studies have shown there is a positive correlation between a low percentage of fetal DNA (i.e. Now doing the waiting game!! Now it is considered high risk and listed a 1/17 chance of a chromosome issue. . I had the first done at 13w and second done at 16w. 0 Many factors may go into your decision to have NIPT and prenatal genetic testing in general. Mine came back inconclusive twice. Trying not to worry.but I am. Your cells are constantly dividing and creating new cells. We strive to provide you with a high quality community experience. (https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC3893900/). it seems to be more common than we think. I have a CVS booked for this Thursday which should give me definitive results but both scans didnt look good so far. NIPT Sex chromosome aneuploidy or fetal sex inconclusive You recently had a blood test to screen for chromosome disorders in the fetus and were told: amount of DNA is from the pregnancy. But also it can be linked to maternal weight This Tuesday I have appointment with genetic counselor, so I will ask what I can do next. Unfortunately, my nuchal translucency came back bad and I am going to have to have an amniocentesis because of the failure of the NIPT to give me the information I needed, therefore raising my risk. 107 0 obj <>stream Hi friend. I dont think Im obese but definitely considered overweight. Ans to top it off I really wanted to find out the gender and now I dont even know if things are ok. Are you tall? Australian post natal pack provided to all new parents. Talk to your healthcare provider or a genetic counselor about your concerns. The DNA is examined for genetic conditions, such as Down syndrome. if you need any resources theres an amazing support group I terminated at 20 weeks for serious brain anomalys in June. She said it worked for almost all her patients. They didnt find anything wrong. u 03-(q}|$05`- H320mf`~e0 * Well, my redraw came back inconclusive, but the NT ultrasounds were reassuring (I am carrying twins). Please specify a reason for deleting this reply from the community. The following questions might be helpful to you as you make your decision: NIPT testing costs vary. Good luck to you! Your DNA is inside all of your cells. So stressful! We do not endorse non-Cleveland Clinic products or services. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. I called the doctors office today to check on my second Panorama test and they informed the test came back again inconclusive due to low fetal fraction. Find advice, support and good company (and some stuff just for fun). My doc told me 2 inconclusive tests raises the risk level significantly in my age. Hi ladies,So I just had a call that my Harmony retest has come back inconclusive. Would I do something different knowing the fetus has a genetic condition or an increased risk for a genetic condition? The educational health content on What To Expect is reviewed by our medical review board and team of experts to be up-to-date and in line with the latest evidence-based medical information and accepted health guidelines, including the medically reviewed What to Expect books by Heidi Murkoff. It doesnt diagnose a condition. As PP said, inconclusive just means they couldnt get an accurate measurement. I've had he NIPT test twice now and had it come back for low fetal DNA. Symptmes de grossesse ne jamais ignorer, Moyens naturels pour dclencher l'accouchement. H Hawaiimomma22 Nov 30, 2017 at 12:44 AM @veneziana, n_qTz Its been so stressful to wait for each of them and then still not have any result at all.. Please select a reason for escalating this post to the WTE moderators: Connect with our community members by starting a discussion. I was 164 pre pregnancy and 184 now. Nothing! I will likely decline invasive testing like amniocentesis. What to Expect supports Group Black and its mission to increase greater diversity in media voices and media ownership. Results from first trimester screening came back low for t21, t13, t18 My doctor just did not liked that NT measured 2.6mm and that was the reason she sent me to do NIPT. In this case, you can repeat the NIPT test and hope for a result the second time. I did have the nt scan with the dr and she said everything looked good and chances for down syndrome was very low but now im panicking I donr know . That is what the clinic told me. Would I consider diagnostic tests like amniocentesis or CVS? Are you taking aspirin? Even though my OB told me it likely wasn't the case for me, I was still in panic mode for a while. endstream endobj startxref Have had an earlier screening test that suggests a potential problem. Just wanted to share my experience since Ive gotten both a CVS and an amniocentesis in the last 3 weeks.Backstory: at my 12 week nuchal translucency scan, we had a high measurement of nuchal fluid (3.5mm). think twice before sharing personal details, foster a friendly and supportive environment, remove fake accounts, spam and misinformation, delete posts that violate our community guidelines, reviewed by our medical review board and team of experts. My Hi all,I had my first NIPT labs drawn around 10 weeks. You wont get the gender but youll find out if baby is healthy x x, Im am from Latvia (Europe). The test is slightly less accurate for detecting trisomy 18 and 13. My doctor told me to test then and acted as if that wasnt too early. Group Owners uphold the core values of the brand by reporting content that violates the community guidelines. All rights reserved. %PDF-1.6 % And if so, what are you going to do? you can always do amnio if you need results. I am assuming they will suggest more invasive testing? Ive heard where some people have a hard time getting results depending on their weight.. Which means your placenta isnt functioning properly? I didnt know that being overweight can affect the NIPT. Inconclusive NIPT results. We respect everyones right to express their thoughts and opinions as long as they remain respectful of other community members, and meet What to Expects Terms of Use. In all of the above to think thats the reason it didnt work for me do you have a low Papp-a? Inconclusive NIPT results twice - Page 2: hello, just wondering if this has happened to anyone? However, its now recommended that providers offer NIPT to all pregnant people, regardless of risk. I had a redraw last week and waiting for that to come back. Note that once you confirm, this action cannot be undone. First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. The main purpose of NIPT is to screen for major chromosome conditions (Down syndrome, trisomy 18, and trisomy 13). The first draw I did at 12 weeks and second draw did at around 13 weeks 6 days. *_xCeEm Di?z&>#m`X_ )= Also I think there's a decent chance at identifying sex at 16 weeks - I had a limited anatomy scan at 13 weeks and the tech said she felt 80% confident identifying one but no clue on the other twin. First test, done at 12 weeks, took 2 weeks for them to get back to me and say was inconclusive, so I had a redraw a week and a half ago at 14 weeks. Policy. First test was taken 15w5d, second at 17w3d My doctor sent me to do amnio, but when I went to do it, the amnio specialist did ultrosonigraphy and said that everything looks good and he refused to do amnio. I had inconclusive NIPT results. Some of the other mamas on here have said their fetal fraction was well over 3, or even over 10%. I took the testing at 16 was I. If youre having a difficult time or wish to discuss the screenings in more detail, a genetic counselor can help you understand the prenatal testing options and what may be a good fit for you. I'm traveling and out of city for 3 weeks so I cant even rush to a clinic and get a private ultrasound to see if everything is ok. Id say if you dont have any family history of issues I bet youll be fine. yes, I have the 12 week scan scheduled for tomorrow evening + bloods then - maybe it will be a different lab this time and it will work. Noninvasive pregnancy screening tests are a personal choice. He sent me to do echocardiography which also was good and show no signs for pathologies. We are going to pursue that because of the rarity of not presenting a result initially. A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. The first test they ran apparently i did not have enough fetal DNA i took another one and the same results, should I be concerned? The doctor said I had a perfect ultrasound. I hate the thought of ending your babys life especially if the doctors have it wrong. Use of this site is subject to our terms of use and privacy policy. I know no words ever make it any justice but very sorry to hear that. Ultimately, we learned we were having a baby girl who did not test positive for trisomy but have still been advised to do an amniocentesis procedure at 16 weeks for ultimate peace of mind.

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